New anti-asthma drugs based on the principle of acupuncture treatment for Asthma
Shanghai University of Traditional Chinese Medicine found the underlying principle of "acupuncture treatment of asthma", is expected to make new anti-asthma drugs thatcould lead to more effective targeted therapy for millions of individuals with asthma...
Acupuncture has been used as an effective alternative treatment of asthma for long time. What's the mechanism behind at the molecular level of this traditional classic acupuncture treatment formular? Published Wednesday(Feb. 8th,2017) in the journal Science Translational Medicine, Professor Yang Yongqing from Shanghai University of Traditional Chinese Medicine led a research team about 10 years after, significant progress has been made in basic research on anti-asthma targeted drugs and acupuncture-effect substances.
In a study, published Wednesday in the journal Science Translational Medicine, Luis Ulloa, a lead author and immunologist at Rutgers New Jersey Medical School, and his collaborator from China's Shanghai University examined more than 6,000 compounds and identified a drug called TSG12 that relaxes the muscles and opens the airways in asthma.
This drug treatment, which is not toxic in human cells, can prevent pulmonary resistance in egg-and dust mite-induced asthma.
Researchers found that a protein called MT-2 in asthmatic lung tissue relaxes airway smooth muscle cells and opens the airways but MT-2 was over 50 percent lower in asthmatic lung tissue.
Ulloa and his collaborators transmitted short electrical pulses into mice through electro-acupuncture needles.
It enabled them to identify the specific drug TSG12 that provides better therapeutic treatments for asthma and other respiratory disorders.
The TSG12 treatment was more effective than current treatments, including bronchodilator inhalers used by almost all people with asthma, Ulloa said...